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Cristal Therapeutics awarded €2.5 million Horizon 2020 grant to advance its CriPec®-docetaxel through Phase 2 trials

Maastricht, The Netherlands, 28 November 2017 – Cristal Therapeutics, a clinical stage biopharmaceutical company developing targeted nanomedicines for the treatment of cancer and other diseases with high unmet patient need, today announced that it secured a €2.5 million grant from the European Commission’s Horizon 2020 programme. The funds will be used to perform the upcoming Phase 2 trials of Cristal Therapeutics’ lead nanomedicine candidate CriPec®-docetaxel to evaluate efficacy and safety in specific solid tumour indications, and to generate supportive evidence for the beneficial bio-distribution profile.

In addition, the grant will support Cristal Therapeutics’ collaboration with various academic and commercial parties to generate clinical trial material and perform several preclinical mechanism of action studies.

CriPec®-docetaxel is a new drug modality that entraps docetaxel, a clinically validated chemotherapy (trade name Taxotere®), as its therapeutic payload into nanoparticles. This nanomedicine candidate is specifically designed to enable enhanced tumour accumulation and sustained drug release at the target site, to boost the therapeutic efficacy and to overcome the shortfalls associated with current docetaxel products, such as the toxic systemic side effects.

Based on preliminary positive Phase 1a results from the open-label, safety and pharmacokinetic study, CriPec®-docetaxel is currently being evaluated in a Phase 1b study to confirm the recommended Phase 2 dose level and treatment regimen.

Dr. Cristianne Rijcken, Cristal Therapeutics’ CSO and Founder said:

“We are delighted that the European Commission has chosen to support the Phase 2 clinical development of CriPec®-docetaxel. Horizon 2020 funding is very competitive and securing this funding is a testament to the exciting clinical potential of our targeted nanomedicine as a superior treatment for patients with solid tumours.”

The funding is from the Phase 2 grants within the SME Instrument of the European Commission’s Horizon 2020 scheme, which supports biotechnology SMEs closing the gap from the lab to the market. There were 1,514 applications for 13 topics. Of these, only 57 were selected for an aggregate funding of Euro 96.8M and Cristal Therapeutics was one of only three successful companies based in The Netherlands.

More information on the Phase 1 study can be found at:
clinicaltrials.gov

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About Cristal Therapeutics

Cristal Therapeutics is a clinical stage biopharmaceutical company developing targeted nanomedicines for the treatment of cancer and other diseases with high unmet patient need and considerable commercial potential. The Company’s product candidates are based on its proprietary CriPec® polymeric nanoparticle technology platform, which enables the design of customised nanomedicines with superior therapeutic profiles. CriPec®-based products have the potential to provide enhanced efficacy and reduced side effect profiles, thus offering improved disease treatment.

The Company’s lead product, CriPec®-docetaxel, is in clinical Phase 1 studies for the treatment of solid tumours. The Company has several other products in preclinical development targeting cancer and inflammatory diseases.

Cristal Therapeutics is a private company that has raised over Euro 19M to date. The Company’s headquarters and laboratories are located in Maastricht, The Netherlands.

Find out more: www.cristaltherapeutics.com

For more information, please contact:

Cristal Therapeutics:
Joost Holthuis, PhD
Chief Executive Officer
Tel: +31 65 435 5535
E: joost.holthuis@cristaltherapeutics.com

Media relations:

Instinctif Partners, London

Lynne Trowbridge / Eileen Paul / Samantha Cheung

Tel: +44 20 7866 7855

E: cristal@instinctif.com

LifeSpring Life Sciences Communication, Amsterdam

Leon Melens

Tel: +31 (20) 705 95 90

E: lmelens@lifespring.nl